nuclear import การใช้

• This section of PRR12 shows a possible nuclear import signal outlined in orange.
• See nuclear import for more about the movement of the ribosomal proteins into the nucleus.
• Iran denies that and charges that Washington has tried to block its civilian nuclear imports from Europe.
• Nuclear import of NFAT proteins is opposed by maintenance kinases in the cytoplasm and export kinases in the nucleus.
• The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals ( NLSs ).
• These changes enhance CPEB3 IPO5 interaction, which consequently accelerates the nuclear import of CPEB3 and promotes its nuclear function.
• Nuclear import depends on the importin binding its cargo in the cytoplasm and carrying it through the nuclear pore into the nucleus.
• It is thought to be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import.
• The importin-alpha / beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal.
• The dark grey lines within the proline rich region and the domain of unknown function are nuclear import and export signals, respectively.
• This encoded protein acts at a relative late stage of nuclear protein import, subsequent to the initial docking of nuclear import ligand at the nuclear envelope.
• These findings place sumoylation at the cytoplasmic filaments of the nuclear pore complex and suggest that, for some substrates, modification and nuclear import are linked events.
• For instance, 14-3-3? controls cellular senescence by nuclear proteins, it likely prevents nuclear import by blocking the nuclear localization signal of target proteins.
• Signal-mediated nuclear import and export proceed through the nuclear pore complex ( NPC ), which is composed of approximately 50 unique proteins collectively known as nucleoporins.
• Vpx is also involved in the nuclear import of the HIV-2 / SIV genomes and associated proteins, but the specific mechanisms and interactions are currently unknown.
• This nuclear import process, mediated by karyopherins, acts on assembled VP1 pentamers in complex with VP2 or VP3; oligomerization to form capsids occurs in the nucleus.
• A signal that appears to be specific for the massively produced and transported ribosomal proteins, seems to come with a specialized set of importin ?-like nuclear import receptors.
• Upon activation, due to hormone binding to ligand binding pocket, the receptor complex has been shown to dissociate, triggering nuclear import and giving the receptor the property of dimerisation ( Fig . 3 ).
• Two functions of Vpr in HIV-1 are split between Vpr and Vpx in HIV-2, with the HIV-2 Vpr protein inducing cell cycle arrest and the Vpx protein required for nuclear import.
• Activated CN rapidly dephosphorylates the serine-rich region ( SRR ) and SP-repeats in the amino termini of NFAT proteins, resulting in a conformational change that exposes a nuclear localization signal, resulting in NFAT nuclear import.